Advances in Managing Infections in Lung Transplantation: A Review

Abstract

Transplanted lung allografts are particularly susceptible to infection among SOT due to the constant exposure to the environment, aggressive immunosuppressive strategies, and impaired clearance mechanisms after denervation of the transplanted lung. Though prophylactic antimicrobial, antifungal, and antiviral regimens are used as preventive strategies to mitigate the risk of infection, complications related to allograft infection remain one of the primary causes of morbidity and mortality after lung transplantation. Here we will review the common bacterial, viral, and fungal complications after lung transplantation, and discuss some newer agents and treatment strategies that have been implemented recently.