Incretin-FGF21 fusion molecule maximizes metabolic effects in mice
Author:
Publisher
China Science Publishing & Media Ltd.
Subject
General Medicine,Biochemistry,Biophysics,Molecular Biology
Link
https://engine.scichina.com/doi/pdf/E5B80B1603D74DF9A8BCF6A2E1C7DBCA
Reference8 articles.
1. Campbell JE, Müller TD, Finan B, DiMarchi RD, Tschöp MH, D’Alessio DA. GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. Cell Metab, 2023, 35: 1519-1529.
2. Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept. Mol Metab, 2018, 18: 3-14.
3. Flippo KH, Potthoff MJ. Metabolic messengers: FGF21. Nat Metab, 2021, 3: 309-317.
4. Harrison SA, Ruane PJ, Freilich BL, Neff G, Patil R, Behling CA, Hu C. Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial. Nat Med, 2021, 27: 1262-1271.
5. Turton MD, O′Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature, 1996, 379: 69-72.
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