Two fighters against oxidative stress in peripheral organs in Parkinson's Disease: Brain-derived neurotrophic factor and hydrogen sulfide

Abstract

Aim: Parkinson's disease, which is a neurodegenerative disorder, has adverse consequences on peripheral organs as well as the brain. This study aims to investigate the effects of brain-derived neurotrophic factor and hydrogen sulfide on liver, kidney, stomach and intestine in Parkinson's disease model created in mice. Materials and Methods: To assess the achievement of the Parkinson's disease model and the effects of brain-derived neurotrophic factor and hydrogen sulfide on this model, animals in all groups were subjected to motor behavior tests. Oxidative stress in peripheral organs was determined biochemically by measuring total oxidant and total antioxidant levels. It was also evaluated histologically in terms of tissue damage and cellular degeneration. Results: According to the motor behaviour tests it was revealed that hydrogen sulfide increased motor performance and coordination against Parkinson's disease and decreased bradykinesia. Experimental Parkinson's Disease and inhibition of the brain-derived neurotrophic factor caused cellular changes in the liver, kidney, and intestine indicating oxidative stress-induced degeneration. It was revealed that hydrogen sulfide protects the histological structure especially in the liver and intestinal tissue and supports the process by increasing the antioxidant capacity in the liver and decreasing the oxidant capacity in the intestine. Conclusion: Brain-derived neurotrophic factor and hydrogen sulfide have different but generaly protective effects on oxidative stress in peripheral organs due to Parkinson's disease.