Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line-Reference-Cited by-同舟云学术

Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line

Published:2024-09-09 Issue:3 Volume:63 Page:441-448
ISSN:1016-9113
Container-title:Ege Tıp Dergisi
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Author:

Kılıç Kubilay Doğan¹^ORCID,Kayabaş Avşar Ayşenur²^ORCID,Özkanca Cemre³^ORCID,Sal Dila Hatun⁴^ORCID,Karabey Fatih⁵^ORCID,Yılmaz Zeynep Simge⁶^ORCID,Uyanıkgil Yiğit⁶^ORCID

Affiliation:

1. EGE ÜNİVERSİTESİ, EGE TIP FAKÜLTESİ

2. CANKIRI KARATEKIN UNIVERSITY

3. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU (İSTANBUL)

4. The University of Sheffield

5. Karabey Cosmetic Productions Limited Company

6. EGE UNIVERSITY, EGE FACULTY OF MEDICINE

Abstract

Objective: The aim of this study was to investigate the cytotoxic effect of Helianthem germanicopolitanum Bornm., a rare endemic plant in Turkey, against colon cancer. Materials and Methods: After the extraction of Helianthemum germanicopolitanum Bornm. plant, the phytochemical profile of the plant was analyzed by High Performance Liquid Chromatography (HPLC). Cytotoxicity analysis on HT-29 human colon cancer cell line was performed by WST 1 assay. The results were compared with other studies on similar plant species in the literature. Results: H. germanicopolitanum plant contains various flavonoids and these flavonoids have cytotoxic effects on colorectal cancer cells. These cytotoxic effects provide anticarcinogenic effects by activating cell death pathways at certain concentrations. These findings provide an important insight into the therapeutic potential of the plant. Conclusion: Cytotoxicity studies of flavonoids in extracts obtained from extraction procedures on colorectal cancer cell lines show that flavonoids offer anticarcinogenic effects by activating cell death pathways at certain concentrations.

Publisher

Ege Journal of Medicine

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