Substitution therapy with levothyroxine in balancing of hormonal interactions at subclinical hypothyroidism in reproductive-age women

Abstract

6 months levothyroxine appointment in 80 reproductive-age women with subtypical hypothyroidism contributed to the normalization of hormonal interactions in the pituitary-ovarian axis with the elimination of reproductive system disorders in 58.8% cases. Hormonal disorders with hyperprolactinemia persisted in 41.2% of women, so they continued substitution therapy with the inclusion of selective dopamine receptor blocker of cabergoline. After 9, and even more after 12 months of this treatment, both the normalization of the hormonal profile and the elimination of clinical manifestations of disorders in the reproductive system were achieved. Key words: hyperprolactinemia, cabergoline, menstrual disorders, reproductive system, hormones.