The Acquired Immune Deficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV) is a leading cause of mortality on the African continent and world. HIV and AIDS are among the greatest public health challenges confronting health authorities around the world. The greatest burden of HIV and AIDS is felt in sub-Saharan countries, with Nigeria and South Africa having the greatest incidence of the disease in the world. AIDS is the final stage of HIV infection, but with effective treatment and healthy living, HIV infection will not develop into AIDS. With increased awareness campaigns by national, regional and international health institutions, there has been an increased awareness on HIV and AIDS across the world. Using data from search query trends on HIV/AIDS submitted online on the most widely used search engine Google from 2004-2019, a decline in search interest for AIDS relative to HIV is revealed in South Africa. This trend mirrors progress on the ground in South Africa, with a decline in AIDS-related deaths and people living longer with the HIV virus. This observed trend might be an indicator that multilateral efforts at combating HIV/AIDS, particularly through awareness raising and behavioural interventions in South Africa is bearing fruit, not just on the ground, but also reflected in the online information seeking on the HIV/AIDS pandemic.