As more Americans are being vaccinated, politicians, institutional leaders, and individual members of the public are debating in what contexts vaccine requirements are appropriate and who should be allowed to set the rules. For example, an increasing number of colleges and universities are announcing that they will require that students be vaccinated before returning to campus in the fall. On the other hand, lawmakers in at least 40 states are seeking to prohibit universities, government agencies, or businesses from doing so.To explore this question, our April 2021 survey (N=21,733 respondents) included a series of questions asking respondents whether or not they approved of local, state, or federal governments mandating vaccines for everyone, and, more narrowly, whether they supported a vaccine requirement to board an airplane, attend (K-12) school in person, or return to college. In this report, we explore public support for such requirements in the aggregate and broken out by demographic subgroups of the population, as well as at the state level.