Molecular Investigations of Sudden Unexplained Deaths

Abstract

Sudden unexplained deaths in apparently healthy individuals (newborn through adult) pose a vexing challenge to medical examiners, law enforcement and society as a whole. Recent advances in “molecular autopsies” have begun to uncover the mystery surrounding sudden unexplained deaths by identifying mutations that can result in or predispose an apparently healthy individual to sudden death. Genetic risks of sudden unexplained deaths have been studied from several different perspectives, and categorized generally by systems, including: cardiac, nervous, immune, and metabolic. This article reviews the genetic risks in sudden unexplained deaths, presents the current state and challenges of molecular investigations, and sheds light on future directions in sudden unexplained death investigations.