Affiliation:
1. Department of Veterinary Clinical Medicine (C.G., M.R.) and Department of Veterinary Pathobiology (K.S.), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL.
Abstract
Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
Publisher
American Animal Hospital Association
Cited by
4 articles.
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1. Histoplasmosis;Greene's Infectious Diseases of the Dog and Cat;2021
2. Life-Threatening Dermatological Emergencies;Textbook of Small Animal Emergency Medicine;2018-10-07
3. Fungal Infections of the Central Nervous System in Small Animals;Veterinary Clinics of North America: Small Animal Practice;2018-01
4. Histoplasmosis;Canine and Feline Infectious Diseases;2014