Long-Term Efficacy of Trilostane Administered Twice Daily in Dogs With Pituitary-Dependent Hyperadrenocorticism-Reference-Cited by-同舟云学术

Long-Term Efficacy of Trilostane Administered Twice Daily in Dogs With Pituitary-Dependent Hyperadrenocorticism

Published:2006-07-01 Issue:4 Volume:42 Page:269-276
ISSN:0587-2871
Container-title:Journal of the American Animal Hospital Association
language:en
Short-container-title:

Author:

Alenza Dolores Perez¹²³,Arenas Carolina¹²³,Lopez Mari Luz¹²³,Melian Carlos¹²³

Affiliation:

1. Veterinary Teaching Hospital (Perez Alenza, Arenas), Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain

2. Clinica Veterinaria Atlantico (Lopez, Melian), Pi y Margall, 42, 35006, Las Palmas de Gran Canaria, Spain

3. From the

Abstract

Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.

Publisher

American Animal Hospital Association

Subject

Small Animals

Link

http://meridian.allenpress.com/jaaha/article-pdf/42/4/269/2376981/0420269.pdf

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