Clinicopathologic Significance of Histologic Grade, Pgp, and P53 Expression in Canine Lymphoma

Author:

Dhaliwal Ravinder S.1,Kitchell Barbara E.1,Ehrhart EJ1,Valli Victor E.1,Dervisis Nikolaos G.1

Affiliation:

1. Center for Comparative Oncology, Michigan State University, East Lansing, MI (B.K., N.D.); Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (E.E.); and VDx Veterinary Diagnostics, Davis, CA (V.V.).

Abstract

To characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades of canine multicentric lymphosarcoma (LSA), 31 cases of LSA without prior treatment were studied. The expression levels of the Pgp and p53 proteins were evaluated for their clinicopathologic significance among standard histologic evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples of 31 previously untreated LSA cases to detect the expression of Pgp and p53. All dogs were subsequently treated with a combination chemotherapy protocol. Remission and survival durations were evaluated for correlation with histologic grade and presence of drug resistance markers. Of the 31 cases, 24 (80%) and 7 (22%) were positive for Pgp and p53, respectively. Overall, the median survival and duration of remission in the study was 246 days and 137 days, respectively. The National Cancer Institute working formulation histologic grade was not associated with either survival or duration of first remission (DOR). The Pgp protein expression and DOR and survival was not statistically significant. Expression of p53 was statistically correlated with survival.

Publisher

American Animal Hospital Association

Subject

Small Animals

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