Immunomodulation therapy for feline leukemia virus infection

Author:

McCaw DL,Boon GD,Jergens AE,Kern MR,Bowles MH,Johnson JC

Abstract

Clinically ill feline leukemia virus (FeLV)-infected cats, treated with Staphylococcus protein A (SPA) or oral interferon alpha (IFN), or both, were compared with cats treated with saline (SAL). Nine cats received SPA/SAL, nine received SPA/IFN, 10 received SAL/IFN, and eight received SAL/SAL. Twelve cats survived and completed the 100-week therapy. Significantly more owners of cats treated with SPA/SAL thought their cat's health improved during treatment compared to owners of cats treated with SAL/SAL (P=0.05, pair-wise comparison) or SPA/IFN (P=0.05, pair-wise comparison). No significant differences in body weight, temperature, hematocrit, red blood cell counts, mean corpuscular hemoglobin concentration, reticulocyte counts, white blood cell or neutrophil numbers, lymphocyte concentrations, bone-marrow cytopathology, FeLV status, survival time, activity, or appetite scores were observed. No significant differences in the owners' subjective assessment of their cat's health following treatment with SAL/IFN, SPA/IFN, or SAL/SAL were seen. Therapy with SPA as a single agent results in the owners' subjective impression of improved health of their FeLV-infected cats.

Publisher

American Animal Hospital Association

Subject

Small Animals

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Therapeutic and Prophylactic Use of Oral, Low-Dose IFNs in Species of Veterinary Interest: Back to the Future;Veterinary Sciences;2021-06-11

2. Interferon therapies in small animals;The Veterinary Journal;2021-05

3. Feline Leukemia Virus Infection;Greene's Infectious Diseases of the Dog and Cat;2021

4. Antiviral Chemotherapy and Immunomodulatory Drugs;Greene's Infectious Diseases of the Dog and Cat;2021

5. Feline leukaemia virus infection: A practical approach to diagnosis;Journal of Feline Medicine and Surgery;2020-08-26

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