Antitumor Effect of Difluoromethylornithine and UFT on Dimethylhydrazine-induced Colon Tumors in Rats

Author:

TSUNODA Akira,SHIBUSAWA Miki,TSUNODA Yuko,YASUDA Naokuni,KOIKE Tadashi

Publisher

The Showa University Society

Reference18 articles.

1. 1) Pegg AE and McCann PP: Polyamine metabolism and function. Am J Physiol, 12: C212-C221 (1982)

2. 2) Russell DH: The roles of polyamines, putrescine, spermidine and spermine in normal and malignant tissues. Life Sci, 13: 1635-1647 (1973)

3. 3) Kingsnorth AN, King WWK, Diekema KA, McCann PP, Ross JS and Malt RA: Inhibition of ornithine decarboxylase with α-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice. Cancer Res, 43: 2545-2599 (1983)

4. 4) Nigro ND, Bull AW and Boyd ME: Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats. Cancer Lett, 35: 153-158 (1987)

5. 5) Tsunoda A, Shirsusawa M, Yasuda N and Koike T: Reduced growth rate of dimethylhydrazineinduced colon tumors in rats: Antitumor effect of difluoromethylornithine. Cancer Res, (1992) in press

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