Cardiac Arrest Due to Capecitabine Toxicosis Treated With ECMO and CRRT: A Case Report

Abstract

Introduction This is the first report of a patient who developed cardiogenic shock after receiving oral chemotherapy with capecitabine and was treated with venoarterial extracorporeal membrane oxygenation combined with continuous renal replacement therapy. Clinical Findings A 58-year-old man developed an arrhythmia that rapidly progressed to cardiogenic shock and cardiac arrest after receiving oral capecitabine tablets to treat a rectal malignancy. Interventions The patient was treated with venoarterial extracorporeal membrane oxygenation in combination with continuous renal replacement therapy. Outcome The patient made a full recovery and was discharged from the hospital. Conclusion The use of comprehensive supportive treatments such as extracorporeal membrane oxygenation combined with continuous renal replacement therapy in patients with capecitabine-induced cardiac arrest can rapidly reduce drug concentrations, eliminate harmful substances, and improve the prognosis.