Euglycemic Diabetic Ketoacidosis Associated With SGLT2 Inhibitor Therapy: A Case Report

Author:

Klinkner Gwen1,Steingraber-Pharr Maggie2

Affiliation:

1. Gwen Klinkner is Diabetes Clinical Nurse Specialist, University of Wisconsin Hospital and Clinics, 600 Highland Ave, MC 6736, Madison, WI 53792 (gklinkner@uwhealth.org).

2. Maggie Steingraber-Pharr is Nurse Practitioner on the Inpatient Diabetes Management Service, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.

Abstract

Sodium-glucose cotransporter-2 inhibitors are now considered second-line treatment agents for type 2 diabetes and offer a unique treatment approach with added cardiorenal benefits. Drugs in this class increase the risk of euglycemic diabetic ketoacidosis, which may be difficult to diagnose if clinicians are not aware of the risk factors and subtle symptoms. This article describes a case of euglycemic diabetic ketoacidosis in a patient with coronary artery disease who was taking a sodium-glucose cotransporter-2 inhibitor and experienced acute mental status changes immediately after heart catheterization.

Publisher

AACN Publishing

Subject

Critical Care Nursing,Emergency Medicine,General Medicine

Reference22 articles.

1. Diabetes care in the hospital;American Diabetes Association Professional Practice Committee;Diabetes Care,2022

2. Diabetic emergencies—ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia;Umpierrez;Nat Rev Endocrinol,2016

3. American Association of Clinical Endocrinologists and American College of Endocrinology position statement on the association of SGLT-2 inhibitors and diabetic ketoacidosis;Handelsman;Endocr Pract,2016

4. Pharmacologic approaches to glycemic treatment;American Diabetes Association Professional Practice Committee;Diabetes Care,2022

5. Cardiovascular disease and risk management;American Diabetes Association Professional Practice Committee;Diabetes Care,2022

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