Cardioprotective Effect of Zinc Oxide Nanoparticles/Green Tea Extract Complex on Monosodium Glutamate Toxicity

Abstract

Monosodium glutamate (MSG) is used worldwide as a food additive, the survey has disclosed some of MSG's deleterious effects on various organs and tissues of rats. This research was achieved to determine the impact of MSG on the albino rats' antioxidant and histology of cardiac tissue. 48 male rats were divided into six groups of eight rats each. Group one used for monitoring and normal saline, whereas rats of group two were given the lower dosage of MSG 6 mg/Kg, rats in group three received 17.5 m/kg body weight of MSG, while rats in group four were given 10 mg/kg body weight of zinc oxide nanoparticles /green tea extract (ZnO NPs/GTE) complex, the fifth and sixth groups were treated with the lower and the higher doses of MSG with ZnO NP/GTE complex for 30 days. Each animal was sacrificed at the end of the treatment period and the heart was thoroughly separated, determining the antioxidant parameter and the histopathological changes. MSG administration to the rats has shown a substantial rise in peroxidation of cardiac heart tissue, decline in the activities of catalase, superoxide dismutase, and glutathione peroxidase beside the decrease in the glutathione level as compared to those in the control animals. The treatment the induced-rats with MSG using complex showed some degree of recovery by a reduction in LPO of the heart and enhancement of antioxidant enzymes. The findings suggested that the intrinsic antioxidant of the heart tissue can significantly be alternated with the use of MSG in a dose-dependent manner and these changes could be improved by using the green ZnO NPs complex. This complex acts as a factor to decrease the histological damage that could be happening by the induction of MSG.