Evaluation of the effectiveness of the drug «Forvet»® in the complex therapy of infectious rhinotracheitis in cats

Abstract

The article presents the results of a multicenter randomized placebo-controlled study of the effectiveness of the drug «Forvet»®. Purpose of research. To determine the effectiveness of the drug «Forvet»® in the complex therapy of infectious rhinotracheitis (herpes virus infection FHV-1) in cats. Materials and methods. The effectiveness of the drug was investigated in a multicenter randomized placebo-controlled study, which was conducted in two veterinary clinics of the Heliet network (Saint Petersburg) in the period from 09.01.2019 to 31.12.2019. The experiment included 120 cats aged 5 to 6 months, weight 1.5... 2 kg, with a diagnosis of «infectious cat rhinotracheitis», based on the results of diagnostic studies (anamnesis, PCR, clinical blood test, body temperature, discharge from the eyes and nasal cavity, the presence of lesions on the mucous membranes). PCR and clinical blood tests were performed on the day of the animal's treatment (to confirm the diagnosis), on the 5th and 10th days of treatment. During the study, the animals were examined by a veterinary specialist with documented clinical signs on the 1st, 3rd, 5th, 7th and 10th days of treatment. The treatment regimen was the same for all animals and included the use of an antibacterial drug (sinulox) for 10 days according to the instructions; eye treatment with lotion (chamomile), eye ointment (tetracycline 1 %) ― 2 times a day,7 days. Group 1 (placebo) was administered an isotonic solution of sodium chloride, group 2 (experimental) was administered the drug «Forvet»®― in a dose of 1 ml, once a day, hypodermically for 10 days. Animals in a serious condition were additionally injected with a 5 % glucose solution ― 50 ml intravenously, once or twice a day, until the appearance of appetite. Results. Based on the analysis of the results of a multicenter randomized placebo-controlled study, the clinical effectiveness of the drug «Forvet»® ― a polysaccharide complex of the class of hexose glycosides as part of the complex therapy of cat herpesvirus infection (FHV pathogen) was established. In the treatment of rhinotracheitis in the group of animals that were used «Forvet»® observed faster elimination of the virus, the return of blood parameters to the limits of the physiological norm, a decrease in the severity of clinical signs of the disease by the fifth day and almost complete clinical recovery by the seventh day of treat