Author:
Haider Nishat,Tyravska Yuliya
Abstract
mean corpuscular volume (MCV) informs a lot about condition of the human body including directly or indirectly signaling about plethora disorders as erythrocytes being an oxygen carrying cells by its indicators’ changes elucidate oxygen content status of the organism. The erythrocytes index parameters particularly MCV can be indicative of the result of the many conditions. In current review the data about MCV variations, namely macro- and microcytosis are systematized and analyzed in further three groups: while physiological conditions of human body (age, sex, pregnancy), in different diseases (variety types of anemias, kidney disorders, endocrine system pathology, cardiovascular disorders, chronic obstructive pulmonary disease) including under the treatment of the latter (antiretroviral treatment of HIV, colorectal cancer, phlebotomy), and caused by iatrogenic influence (toxins, smoking, alcohol drinking). Current minireview includes mindful analysis of 20 trials published in PubMed database.
Publisher
Scientific Publishing Center InterConf
Reference23 articles.
1. Kauffmann T, Evans DS. Macrocytosis. 2022 Sep 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32809743.
2. Sarma PR. Red Cell Indices. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990. Chapter 152. PMID: 21250103.
3. Hoffmann JJ, Nabbe KC, van den Broek NM. Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV). Clin Chem Lab Med. 2015 Nov;53(12):2015-9. doi: 10.1515/cclm-2015-0155.
4. Milovanovic M, Nilsson S, Winblad B, Jelic V, Behbahani H, Shahnaz T, et al. Inverse relationship between erythrocyte size and platelet reactivity in elderly. Platelets. 2017 Mar;28(2):182-186. doi: 10.1080/09537104.2016.1206196.
5. Monteiro MG, Masur J. Monitoring alcoholism treatment: the appropriateness of choice between gamma GT or MCV evaluation after a short time of abstinence. Alcohol. 1986 Jul-Aug;3(4):223-6. doi: 10.1016/0741-8329(86)90029-7.