Rivaroxaban and Dabigatran: prospects for use in the management of heart failure

Abstract

Scientific articles examine the effectiveness and pharmacokinetics of two oral anticoagulants, dabigatran and rivaroxaban, in the context of treating atrial fibrillation and chronic heart failure. Dabigatran, as a direct thrombin inhibitor, influences the thrombin zone and fibrinogen, preventing fibrin formation. Rivaroxaban, as a selective factor Xa inhibitor, blocks factor X activation. Both medications demonstrate high bioavailability and plasma protein binding. Studies on the efficacy of rivaroxaban in atherosclerosis and low-dose rivaroxaban in chronic heart failure did not reveal statistically significant reductions in cardiovascular risk. The findings emphasize the importance of further research and an individualized approach to selecting anticoagulants for optimal management of patients with diverse cardiovascular conditions.