Reporting Essentials for DElirium bioMarker Studies (REDEEMS): Explanation and Elaboration

Author:

Amgarth-Duff Ingrid12ORCID,Hosie Annemarie134,Caplan Gideon A.56,Adamis Dimitrios7,Watne Leiv Otto89,Cunningham Colm1011,Oh Esther S12,Wang Sophia1313,Lindroth Heidi141516,Sanders Robert D1718,Olofsson Birgitta19,Girard Timothy D20,Steiner Luzius A21,Vasunilashorn Sarinnapha M222324,Agar Meera12526

Affiliation:

1. University of Technology Sydney, IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), Sydney, NSW, Australia

2. Telethon Kids Institute, Perth, Western Australia

3. The University of Notre Dame Australia, School of Nursing & Midwifery, Darlinghurst, NSW, Australia

4. St Vincent’s Health Network Sydney, The Cunningham Centre for Palliative Care, Darlinghurst, NSW, Australia

5. Prince of Wales Clinical School, University of New South Wales, Randwick, NSW, Australia

6. Prince of Wales Hospital, Randwick, NSW, Australia

7. Sligo Mental Health Services, Clarion Road, Sligo, Ireland

8. Oslo Delirium Research Group, Department of Geriatric Medicine

9. Oslo University Hospital, Oslo, Norway

10. Trinity Biomedical Sciences Institute

11. Trinity College Institute of Neuroscience, Trinity College, Dublin

12. John Hopkins University School of Medicine, Baltimore, MD, USA

13. Indiana University School of Medicine, Indianapolis, IN

14. Mayo Clinic, Department of Nursing, Division of Nursing Research, Rochester, MN

15. Indiana University, School of Medicine, Center for Health Innovation and Implementation Science

16. Regenstrief Institute

17. University of Sydney, Camperdown, Sydney, NSW, Australia

18. Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia

19. Umeå University, Sweden

20. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

21. University of Basel, Basel, Switzerland

22. Beth Israel Deaconess Medical Centre, Boston, Massacheusetts, USA

23. Harvard Medical School, Boston, Massacheusetts, USA

24. Harvard T.H Chan, School of Public Health, Boston, Massacheusetts, USA

25. South West Sydney Clinical School, University of New South Wales, Liverpool, New South Wales, Australia

26. Ingham Institute of Applied Medical Research, Liverpool, New South Wales, Australia

Abstract

Despite many studies of potential delirium biomarkers, delirium pathophysiology remains unclear. Evidence shows that the quality of reporting delirium biomarker studies is sub-optimal. Better reporting of delirium biomarker studies is needed to understand delirium pathophysiology better. To improve robustness, transparency and uniformity of delirium biomarker study reports, the REDEEMS (Reporting Essentials for DElirium bioMarker Studies) guideline was developed by an international group of delirium researchers through a three-stage process, including a systematic review, a three-round Delphi study, and a follow-up consensus meeting. This process resulted in a 9-item guideline to inform delirium fluid biomarker studies. To enhance implementation of the REDEEMS guideline, this Explanation and Elaboration paper provides a detailed explanation of each item. We anticipate that the REDEEMS guideline will help to accelerate our understanding of delirium pathophysiology by improving the reporting of delirium biomarker research and, consequently the capacity to synthesise results across studies.

Publisher

European Delirium Association

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