The impact of the diffusion parameter on the passage time of the folding process

Abstract

Recently, a mathematical method to solve the Fokker Plank equation (FPE) enabled the analysis of the protein folding kinetics, through the construction of the temporal evolution of the probability density. A symmetric tri-stable potential function was used to describe the unfolded and folded states of the protein as well as an intermediate state of the protein. In this paper, the main points of the methodology are reviewed, based on the algebraic Supersymmetric Quantum Mechanics (SQM) formalism, and new results on the kinetics of the evolution of the system characterized in terms of the diffusion parameter are presented.