Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2<i>H</i>-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives-Reference-Cited by-同舟云学术

Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2<i>H</i>-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives

Published:2016-11-30 Issue: Volume:71 Page:19-28
ISSN:2299-3843
Container-title:International Letters of Chemistry, Physics and Astronomy
language:
Short-container-title:ILCPA

Author:

Shah Nilay¹,Patel Pineshkumar N.²,Rajani Dhanji³,Karia Denish C.⁴

Affiliation:

1. Cadila Health Care Pvt. Ltd

2. Huntsman International India Pvt. Ltd

3. Microcare Laboratories and Tuberculosis Research Center

4. Patel J D K Davolwala Science College

Abstract

In present work, novel derivatives of substituted N-(4-(8-methoxy-2-oxo-2H-chromen-3-yl) thiazol-2-yl) amide have been synthesized. The solvent free reaction of 2-Hydroxy-3-methoxybenzaldehyde with Ethyl acetoacetate in presence of Piperidine catalyst produces 3-acetyl-8-methoxy-2H-chromen-2-one (C). Compound C was α- brominated using CuBr2 and subsequently cyclized using Thiourea to produce 3-(2-aminothiazol-4-yl)-8-methoxy-2H-chromen-2-one as main scaffold (E). This scaffold E was finally reacted with different Acid chloride to isolate title compound derivatives. The chemical structures of synthesized compounds were confirmed by 1H-NMR, FT-IR and Mass spectral/LCMS analysis. The synthesized compounds were screened for potential Antimicrobial, Antifungal and Antimalarial activity.

Publisher

AOA Academic Open Access Ltd.

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

Link

https://www.academicoa.com/ILCPA.71.19.pdf

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