Synthesis and Structure of New Compounds NSAIDs-Like Using a Heterogeneous Recyclable Catalyst

Author:

Alkayal Anas1,Keshe Mohammad1,Madwar Rushdi1,Sarko Dikran1,Karam Ayman2

Affiliation:

1. University of Al-Baath Homs

2. Université de Poitiers

Abstract

In this research, Phenol derivatives have been reacted with aryl halides using 5 mol% Cu(I) Complex [CuClPPh3]4 as catalyst supported on Amberlyst A21. The typical reaction has been performed between p-cresol and bromobenzene. This reaction is achieved in o-xylene as solvent. However, the catalyst complex does not dissolve in o-xylene rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compounds were prepared by reacting some of bromoaryl derivatives with some Phenol derivatives. It is anticipated that the synthesized compounds have a structure NSAIDs-likes that may find their applications in the pharmaceutical industries.

Publisher

AOA Academic Open Access Ltd.

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

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