Synthesis and Nitration of 7-Hydroxy-4-Methyl Coumarin via Pechmann Condensation Using Eco-Friendly Medias-Reference-Cited by-同舟云学术

Synthesis and Nitration of 7-Hydroxy-4-Methyl Coumarin via Pechmann Condensation Using Eco-Friendly Medias

Published:2016-08-12 Issue: Volume:69 Page:66-73
ISSN:2299-3843
Container-title:International Letters of Chemistry, Physics and Astronomy
language:
Short-container-title:ILCPA

Author:

Hussien Fadia Al Haj¹,Keshe Mohammad¹,Alzobar Khaled¹,Merza Joumaa¹,Karam Ayman²

Affiliation:

1. University of Al-Baath Homs

2. Université de Poitiers

Abstract

A nitro coumarin derivatives has been synthesized via nitration of 7-hydroxy-4-methyl coumarin wich was synthesized via Pechmann condensation resorcinol with a β-ketoester using Amberlyst-15 as a green and efficient catalyst and by caring out the reaction of resorcinol and ethyl acetoacetate (with 1: 1 mol ratio) in the presence of 0.2 g of Amberlyst-15 at 110°C under solvent-free conditions. These nitro coumarin derivatives have biological activity and momentousness in the industrial fields. The purified products were measured the melting points and characterized by spectral methods: FT-IR, 1H-NMR , 13C-NMR.

Publisher

AOA Academic Open Access Ltd.

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

Link

https://www.academicoa.com/ILCPA.69.66.pdf

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