Cephradine Intercalated Mg-Al Layered Double Hydroxide

Abstract

Engineered advanced functional materials are promising candidates for biotechnology and biomedical science. Mg-Al layered double hydroxide (LDH), anionic or hydrotalcite-like clays consist of positively charged layers and exchangeable anions along with water molecules in the interlayer space were synthesized from homogeneous solution of MgCl2 and AlCl3 by urea induced co-precipitation method. A pharmaceutically important drug, cephradine was intercalated with synthesized LDH in alkali media (pH 10) by in-situ technique. Characterizations of the products were carried out using Attenuated Total Reflectance Infra-red (ATR-IR), Energy Dispersive X-ray (EDX) and X-ray Diffraction (XRD) spectroscopy. Scanning electron morphological images envisaged a distinct crystalline and amorphous phases of Mg-Al LDH before and after modification with cephradine. Intercalation of bioactive molecules with LDH would enhance their stability providing sustained release behavior in physiological environment.