Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus-Reference-Cited by-同舟云学术

Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

Published:2019-01-22 Issue:6 Volume:56 Page:785-790
ISSN:1995-4492
Container-title:Rheumatology Science and Practice
language:
Short-container-title:Naučno-praktičeskaâ revmatologiâ

Author:

Vorobyeva L. D.¹,Aseeva E. A.¹,Solovyev S. K.¹,Belousova T. A.²,Lopatina N. E.¹,Sazhina E. G.¹,Serikova G. V.¹

Affiliation:

1. V.A. Nasonova Research Institute of Rheumatology.

2. Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia.

Abstract

Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.

Publisher

Mediar Press

Subject

Immunology,Immunology and Allergy,Rheumatology

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