Affiliation:
1. Pirogov Russian National Research Medical University, Ministry of Health of Russia
2. JSC "European Medical Center"
3. JSC "European Medical Center";
Belgorod State National Research University
4. Pirogov Russian National Research Medical University, Ministry of Health of Russia;
JSC "European Medical Center";
Russian Medical Academy of Continuing Professional Education
Abstract
Hypogammaglobulinemia is a condition caused by low levels of immunoglobulins in the blood serum. It can be a manifestation of primary immunodeficiency, characterized by a violation of the production of immunoglobulins, in particular common variable immunodeficiency (CVID). A typical clinical sign of CVID is various severe infections, among which infectious arthritis is not uncommon. At the same time, the clinical picture of infections can differ significantly from that in individuals with a normal immune response, including the spectrum of infectious arthritis pathogens.The article describes a clinical case of an unusual course of infectious arthritis in a patient with newly diagnosed hypogammaglobulinemia. The peculiar features of the case were a long (more than 1.5 years) course of the disease, without the development of septic complications, no increase in ESR and CRP, recurrence of arthritis after a 2-month course of antibiotic therapy, and the presence of generalized edema. The causes and diagnosis, features of infectious complications, including infectious arthritis, and probable causes of edematous syndrome in CVID are discussed.
Subject
Pharmacology (medical),Immunology,Immunology and Allergy,Rheumatology