Analysis of the mechanisms of development of neurorheumatological consequences of COVID-19 and the possibility of their pharmacological correction-Reference-Cited by-同舟云学术

Analysis of the mechanisms of development of neurorheumatological consequences of COVID-19 and the possibility of their pharmacological correction

Published:2022-05-06 Issue:2 Volume:16 Page:92-98
ISSN:2310-158X
Container-title:Modern Rheumatology Journal
language:
Short-container-title:Sovremennaâ revmatologiâ

Author:

Sarvilina I. V.¹^ORCID,Lila A. M.²^ORCID,Gromova O. A.³^ORCID,Torshin I. Yu.³^ORCID,Shavlovskaya O. A.⁴^ORCID,Taskina E. A.⁵^ORCID

Affiliation:

1. Medical Center «Novomeditsina»

2. V.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional Education

3. Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control»

4. International University of Restorative Medicine

5. V.A. Nasonova Research Institute of Rheumatology

Abstract

We present the review of clinical and experimental studies on the pathogenesis of neurorheumatological complications (NRC) in COVID-19. The influence of systemic hyperinflammation caused by impaired innate immunity on the functioning of the neurovascular endothelium and the bloodbrain barrier, activation of signaling pathways of innate immunity and parainfectious autoimmunity in the central nervous system were analyzed.Hyperinflammation has been shown to contribute to the development of NRC in COVID-19. The potential therapeutic efficacy of drugs, including those based on chondroitin sulfate, which can be used for the prevention and treatment of NRC in COVID-19, is considered.

Publisher

IMA Press, LLC

Subject

Pharmacology (medical),Immunology,Immunology and Allergy,Rheumatology

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