Viral mixed infection complicated by acute hepatitis and allergic toxic dermatitis (clinical case)

Author:

Aronova E. S.1ORCID,Belov B. S.1ORCID,Gridneva G. I.1ORCID

Affiliation:

1. V.A. Nasonova Research Institute of Rheumatology

Abstract

Epstein-Barr virus (EBV) belongs to the family of herpesviruses (herpes type 4) and is one of the most common and highly contagious. During the pandemic of a new coronavirus disease, it was found that in patients previously infected with EBV, COVID-19 can cause its reactivation, which is often manifested by the clinic of acute hepatitis. The article presents a clinical case of the development of acute hepatitis in a patient with mixed infection with EBV and SARS-CoV-2 in combination with allergic toxic reaction while taking sulfasalazine prescribed for spondyloarthritis. A feature of this case was the development of severe hepatitis of mixed genesis with a favorable outcome. The importance of adherence to drug monitoring rules for newly prescribed drugs for COVID-19 was emphasized. In severe cases of the disease, the possibility of mixed infection should be taken into account.

Publisher

IMA Press, LLC

Subject

Pharmacology (medical),Immunology,Immunology and Allergy,Rheumatology

Reference23 articles.

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3. Federal'nye klinicheskie rekomendatsii po vedeniyu bol'nykh sindromom Stivensa– Dzhonsona / toksicheskim epidermal'nym nekrolizom [Federal clinical guidelines for the management of patients with Stevens—Johnson syndrome / toxic epidermal necrolysis]. Moscow: Rossiiskoe obshchestvo dermatovenerologov i kosmetologov; 2015.

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