Experience with type I interferon inhibitor in systemic lupus erythematosus

Author:

Leineman Ya. A.1ORCID,Bessalova A. Yu.1ORCID,Aliev D. B.1ORCID,Samigullina R. R.1ORCID,Shostak M. S.1ORCID,Gaidukova I. Z.1ORCID,Mazurov V. I.1ORCID

Affiliation:

1. North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia

Abstract

The article describes a clinical case of systemic lupus erythematosus (SLE) resistant to traditional treatment regimens and the first successful experience with the type I interferon inhibitor – anifrolumab, as part of an early access program in the Russian Federation. High efficacy and safety of the drug in the treatment of SLE with active lesions of the skin, mucous membranes and joints were noted.

Publisher

IMA Press, LLC

Subject

Pharmacology (medical),Immunology,Immunology and Allergy,Rheumatology

Reference18 articles.

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3. Gaidukova IZ, Mazurov VI, Inamova OV, et al. Disease activity and comorbidities in patients with systemic lupus erythematosus — what has changed in two decades? Russkii meditsinskii zhurnal. 2021;(1):2-6. (In Russ.).

4. Fanouriakis A, Kostopoulou M, Alunno A, et al. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis. 2019 Jun;78(6):736-745. doi: 10.1136/annrheumdis-2019-215089.

5. Zahr ZA, Fang H, Magder LS, Petri M. Predictors of corticosteroid tapering in SLE patients: the Hopkins Lupus Cohort. Lupus. 2013 Jun;22(7):697-701. doi: 10.1177/0961203313490434. Epub 2013 May 24.

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