CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS-Reference-Cited by-同舟云学术

CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS

Published:2018 Issue:36 Volume: Page:
ISSN:2313-2396
Container-title:The Journal of V. N. Karazin Kharkiv National University, Series "Medicine"
language:
Short-container-title:

Author:

Abstract

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

Publisher

V. N. Karazin Kharkiv National University

Reference13 articles.

1. Picard C. et al. Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015 // Journal of clinical immunology. – 2015. – Т. 35. – No. 8. – p. 696–726.

2. Picard C. et al. International union of immunological societies: 2017 primary immunodeficiency diseases committee report on inborn errors of immunity // Journal of clinical immunology. – 2018. – Т. 38. – No. 1. – p. 96–128.

3. Kucuk Z. Y. et al. CTP synthase 1 deficiency in successfully transplanted siblings with combined immune deficiency and chronic active EBV infection // Journal of clinical immunology. – 2016. – Т. 36. – No. 8. – p. 750–753.

4. Kim H. J. et al. Systemic multi-organ involvement in chronic active Epstein-Barr virus disease // Pediatrics International. – 2015. – Т. 57. – No. 4. – p. 802–804.

5. Amer A. et al. Epstein Barr virus infection was associated with nephrotic syndrome, severe thrombocytopenia and coombs positive haemolytic anaemia // Acta Paediatrica. – 2018.