ASSESSMENT OF IgG AUTOANTIBODIES TO SINGLE-STRANDED DNA (ss-DNA) AND DOUBLE-STRANDED DNA (ds-DNA) IN PATIENTS WITH ACANTHOLYTIC PEMPHIGUS-Reference-Cited by-同舟云学术

ASSESSMENT OF IgG AUTOANTIBODIES TO SINGLE-STRANDED DNA (ss-DNA) AND DOUBLE-STRANDED DNA (ds-DNA) IN PATIENTS WITH ACANTHOLYTIC PEMPHIGUS

Published:2020 Issue:4 Volume:6 Page:57-62
ISSN:2414-3782
Container-title:Juvenis Scientia
language:
Short-container-title:Juvenis scientia

Author:

Mavlyanova Sh. Z.¹,Mutavaliev M.S.¹,Ismogilov A.I.¹,Mullakhanov J.B.¹^ORCID,Alimukhamedova Yu. A.¹

Affiliation:

1. Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology

Abstract

In recent years, evaluation of autoimmune mechanisms of bullous dermatoses has become relevant. In this connection, the aim of our study was to assess serum levels of IgG autoantibodies (AAB) to single stranded DNA (ss-DNA) and double stranded DNA (ds-DNA) in patients with true acantholytic pemphigus. The present study included 57 patients with acantholytic pemphigus and 18 healthy individuals (control group). Analysis of the results obtained showed that most patients with true pemphigus had an increased level of IgG autoantibodies to ds-DNA (59.6% of cases). At the same time, IgG autoantibodies to ss-DNA were detected in 15.8% of cases. Quantitative evaluation of the serum level of IgG autoantibodies to ds-DNA revealed an increase by 1.6 times in patients with pemphigus as compared to the control group (p<0.05). The data obtained have diagnostic and prognostic value for the clinical course of the disease. In our opinion, the serum level of IgG autoantibodies should be taken into account for choosing optimal treatment strategies.

Publisher

Scientia Publishing House LTD

Subject

General Medicine

Reference24 articles.

1. Лепехова А.А. Стероидрезистентная форма истинной акантолитической пузырчатки, разработка и обоснование рациональной фармакотерапии: автореф. дис. … канд. мед. наук.: 2015.

2. Lepekhova AA. Steroid-resistant form of true acantholytic pemphigus, development and justification of rational pharmacotherapy: diss.. abst.. 2015. (In Russ).

3. Лысенко А.А. Анализ роли дистальных доменов десмоглеина 3 человека в нарушении адгезии между кератиноцитами при пузырчатке: автореф. дис. … канд. биолог. наук.: 2009

4. Lysenko AA. Analysis of the role of distal domains of human desmoglein 3 in impaired adhesion between keratinocytes in pemphigus: diss.. abst.. 2009. (In Russ).

5. Мавлянова Ш.З., Убайдуллаев А.А. Клиническое течение акантолитической пузырчатки в современных условиях Узбекистана // Дерматовенерология и эстетическая медицина. 2009. № 1. С. 82-85.