ASSESSMENT OF THE STATE OF THE SKIN MICROBIOME OF PATIENTS WITH ALLERGODERMATOSES

Abstract

<br><b>Introduction</b>. Recently, special attention has been paid to opportunistic microorganisms that inhabit biosubstrates - the skin and mucous membranes of the human body. <br><b>Patients and Methods</b>. To assess the microbiome of the skin in patients with allergic dermatoses, we carried out microbiological studies of the skin in 456 patients aged from 3 to 67 years. Microbiological studies included bacterioscopic and cultural examination of skin flakes from lesions in patients with allergic dermatoses. <br><b>Results</b>. Our clinical and microbiological studies of 456 patients with allergic dermatoses showed that <i>Staphylococcus spp.</i> was detected on the skin lesions of 429 patients (94.08%), including those with atopic dermatitis - 230 (53.61%), urticaria - 47 (10.96%), toxicoderma - 48 (11.19%) and erythema multiforme - 22 (5.13%). The most common species of microorganisms observed in patients with allergic dermatoses included <i>S. aureus</i> in 46.6% (200) and <i>S. epidermidis</i> in 29.1% (125) cases, followed by <i>S. haemolyticus</i> in 14.2% (61), <i>S. saprophyticus</i> in 5.6% (24), <i>Enterobacter</i> in 3.9% (17) and <i>S. pyogenes</i> in 0.5% (2) patients. In 34.8% of cases, we found microbial contamination with pathogenic forms of <i>Staphylococcus spp.</i>, which determined the development of a mixed-bacterial form of an invasive process in the skin lesions of patients with allergic dermatoses. <br><b>Conclusion</b>. The data obtained are of great importance with regard to the clinical course of allergic dermatoses and will contribute to the development of new methods of pathogenetic therapy.