Pulmonary Lymphomatoid Granulomatosis in a Dog: Evidence of Immunophenotypic Diversity and Relationship to Human Pulmonary Lymphomatoid Granulomatosis and Pulmonary Hodgkin's Disease

Author:

Park H.-M.1,Hwang D.-N.2,Kang B.-T.1,Jung D.-I.1,Song G.-S.2,Lee S.-J.2,Yhee J.-Y.2,Yu C.-H.2,Doster A. R.3,Sur J.-H.2

Affiliation:

1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Kwangjin-Ku, Seoul, Korea

2. Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Kwangjin-Ku, Seoul, Korea

3. Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska

Abstract

We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg–like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.

Publisher

SAGE Publications

Subject

General Veterinary

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