Author:
Christopherson P. W.,Insalaco T. A.,Santen V. L. van,Livesey L.,Bourne C.,Boudreaux M. K.
Abstract
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin αIIbβ3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.
Cited by
25 articles.
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