Utilization derivatives of 4 - [4-(acetylamino)phenyl]-2 - (3,5 dimethyl - 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid in Heterocyclic Synthesis and Study of Their Biological Activities

Abstract

The aim of this research the derivatives of 4- [4-(acetylamino) phenyl]- 2 -(3,5dimethyl- 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid was used synthesize heterocyclic compounds. These heterocyclic compounds could be used as the main feedstock to prepare heterocyclic compounds (6,5 membred ring) including thiadiazolo, imidazole and pyridazinone derivatives. The effect of nucleophilic and electrophilic reagents on the resulting pyridazinones compounds was studied. Through preliminary analyzes of the compounds prepared in the research and spectroscopic data which obtained their structures were proved, and it have biological activities.