THE IMPORTANCE OF MYOSIN AND ACTIN CALCIUM-DEPENDENT REGULATORY COMPLEX MARKERS IN THE CLINICAL AND DIAGNOSTIC MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION

Abstract

Currently cardiovascular diseases are one of the main causes of mortality worldwide, one of the most important is the Acute Myocardial Infarction (AMI), its early diagnosis for patient survival is extremely necessary. Biochemical markers of myocardial injury have the function of facilitating the diagnosis of these cardiac events. The present study aimed to evaluate the accuracy, as well as the limitations of the cardiac biomarkers of troponins and myoglobin as an aid in acute myocardial infarction. It was possible to observe that recently, troponins have received increasing attention as extremely specific markers of cellular injury, these form a complex that regulates the calcium-dependent interaction of myosin with actin, being constituted of three different proteins (troponin I, C and T ) existing in both skeletal and cardiac muscle and encoded by different genes. Acute circulatory failure causes cellular changes that can vary from small losses of some membrane properties to cell death. With this it is possible to conclude that in some intracellular substances gain the interstitial space and blood circulation, resulting in a transient increase in circulating levels, aspartate aminotransferase, myoglobin, creatine kinase, lactic dehydrogenase, troponins, among others, being identified as cardiac injury markers represent great tools that help in the diagnosis of acute myocardial infarction