Sinomenine Suppresses Cell Progression and Induces Cell Apoptosis by Regulating AKT/mTOR Signaling Pathway in Cutaneous Squamous Cell Carcinoma Cells

Abstract

While sinomenine plays a crucial anticancer role in a variety of cancers, its function and molecular mechanism in cutaneous squamous cell carcinoma remains unexplored. To this end, we explored the effect of sinomenine on cell viability, colony formation rate, cell apoptosis rate, and migration and invasion and wound healing in A431 and SCL-1 cells representing cutaneous squamous cell carcinoma. The results show that sinomenine inhibited cutaneous squamous cell carcinoma viability, clone formation, migration and invasion, induced cell apoptosis by inactivating AKT/mTOR pathway. These data may likely to provide a novel candidate for treating patients diagnosed with cutaneous squamous cell carcinoma.