Evaluation of the Laxative-Like Activity of Andrographis Paniculata-Reference-Cited by-同舟云学术

Evaluation of the Laxative-Like Activity of Andrographis Paniculata

Published:2022-03-23 Issue:1 Volume:20M Page:M17-M23
ISSN:1540-7535
Container-title:Current Topics in Nutraceutical Research
language:en
Short-container-title:CTNR

Author:

Tandur Vijayamahantesh K.¹²,Inamdar Mohammed Naseeruddin¹³,Asdaq Syed Mohammed Basheeruddin²,Rabbani Syed Imam⁴,Alamri Abdulhakeem⁵⁶,Alhomrani Majid⁵⁶,Alsanie Walaa F.⁵⁶

Affiliation:

1. Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India

2. Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713, Riyadh, Saudi Arabia;

3. Present address: Department of Pharmacology, East West College of Pharmacy, Bangalore, India

4. Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Kingdom of Saudi Arabia;

5. Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia and

6. Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi Arabia.

Abstract

Herbal medicine has been used since ancient times to treat chronic constipation. The present study has investigated the gut stimulatory activity of Andrographis peniculata, an herbal medicine common to many parts of the globe. Results of these studies show a dose-dependent increase in the contraction of smooth muscle from isolated rat colon, guinea pig ileum, and rabbit jejunum by A. peniculata extracts. Furthermore, it enhanced intestinal fecal transit in mice. Additional studies into its action suggested the involvement of a cholinergic mechanism.

Publisher

New Century Health Publishers LLC

Subject

Nutrition and Dietetics,Medicine (miscellaneous)