Role of Nutrients on Platelets Participation in Leukocyte Recruitment and Inflammation Resolution in Inflammatory Diseases, Including Covid-19

Abstract

Interactions of platelets with circulating cells and vessel walls are implicated in various inflammatory processes. In certain circumstances, the hemostatic and inflammatory functions of platelets may overlap. Platelet–lymphocyte/leukocyte interactions can effectively regulate chronic inflammatory conditions. Platelet extracellular vesicles play a prominent role in thrombosis. In this review, we provide an overview of the molecules associated with platelet–cell interaction and the role of platelet extracellular vesicles in cardiovascular disorders and coronavirus disease 2019, which has posed a significant threat to global health due to infection with severe acute respiratory syndrome coronavirus 2. In addition to recruiting leukocytes to resolve inflammation associated with inflammatory diseases, such as coronavirus disease 2019, nutrients may also play a significant role in human metabolism.