Protective Effect of Hispolon on Postoperative Cognitive Dysfunction in a Sevoflurane-Induced HT-22 Cell Model

Abstract

Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction.