Inhibitory Effect of Poria cocos Polysaccharides on Proliferation, Migration, and Invasion of Lung Cancer Cells, A549

Abstract

We have investigated the inhibitory effect of polysaccharides of Poria cocos on the proliferation, migration, and invasion of A549 lung cancer cells. The results showed that compared to the control group, the proliferation, migration, and invasion ability of all the treatment groups were inhibited, and the expression levels of ki-67 protein, matrix metalloproteinase-2, and matrix metalloproteinase-9 were also inhibited (P < 0.05). Moreover, polysaccharides of P. cocos significantly inhibited the expression of nuclear factor-kappa B (NF-κB) signaling pathway related genes p-p65 and p-IκB (P < 0.05). In conclusion, the mechanism of the inhibition of proliferation, migration, and invasion of lung cancer A549 cells by the polysaccharides of P. cocos may involve the inhibition of the NF-κB signaling pathway.