Erianin Regulates PI3K/AKT Signaling Pathway and Inhibits Cell Invasion and Migration in Gastric Cancer In Vitro

Abstract

Gastric carcinoma is one of the most malignant cancers associated with lifestyle and genetics. The currently used pharmacotherapeutics are associated with serious side effects necessitating a need for safer drugs. Erianin is a natural plant bioactive substance known for its anti-cancerous and a variety of other biologic activities. Using a variety of measures such as colony formation, invasion and migration assay, and flow cytometry and apoptosis, we have examined the effect of erianin on human gastric adenocarcinoma cells representing gastric carcinoma. The results show that erianin ensured (i) inhibition of proliferation, invasion, and migration capabilities, (ii) induction of apoptosis, and (iii) inhibition of the activation of phosphatidylinositol 3-kinase/Protein kinase B signaling pathway. In conclusion, these results show a potential for erianin in the management of gastric carcinoma.