Antcin C Enhances Cellular Apoptosis of Hepatic Carcinoma Cells by Modulating Phosphoinositide 3-Kinases/Protein Kinase B/The Mammalian Target of Rapamycin Pathway

Abstract

The present study has evaluated the role of Antcin C in hepatic carcinoma and its possible mechanism of action. The results show that Antcin C causes a significant dose-dependent reduction in cell viability, cell migration and invasion, and enhancement of apoptosis. Moreover, treatment with Antcin C significantly reduces the expression of phosphoinositide 3-kinases/protein kinase B protein in Hep-G2 cells in a concentration-dependent manner. In conclusion, data of the present investigation supports that Antcin C enhances apoptosis in hepatic carcinoma by inhibiting the phosphoinositide 3-kinases/ protein kinase B pathway.