1. Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 23142, Taiwan;
2. Department of Pediatrics, School of Medicine, Tzu Chi University, Hualien 97071, Taiwan;
3. Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan;
4. Institute of Biomedical Sciences, Academia Sinica, Taipei City 115201,Taiwan; and
5. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan