The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors-Reference-Cited by-同舟云学术

The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors

Published:2008-12-31 Issue:1 Volume:9 Page:29-36
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Chirgadze N.Y.,Sall D.J.,Briggs S.L.,Clawson D.K.,Zhang M.,Smith G.F.,Schevitz R.W.

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference36 articles.

1. Crystallographic analysis at 3.0 Å resolution of the binding to human thrombin of four active site-directed inhibitors;Banner;J Biol Chem,1991

2. Thrombotic processes in cerebrovascular disease;Barnett;J Biol Chem,1991

3. The refined 1.9 A crystal structure of human α-thrombin: Interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment;Bode;EMBO J,1989

4. The refined 1.9 Å X-ray crystal structure of D-Phe-Pro-Arg chlormethylkethone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties. Detailed active site geometry and structure-function relationships;Bode;Protein Sci,1992

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