A NEW APPROACH TO MORPHOLOGICAL EVALUATION OF THE DEGREE OF LIVER FIBROSIS IN EXPERIMENTAL ANIMALS-Reference-Cited by-同舟云学术

A NEW APPROACH TO MORPHOLOGICAL EVALUATION OF THE DEGREE OF LIVER FIBROSIS IN EXPERIMENTAL ANIMALS

Published:2022 Issue:1 Volume:58 Page:92-100
ISSN:2078-0109
Container-title:Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine
language:ru
Short-container-title:

Author:

Lebedeva E.I.¹^ORCID,Shchastny A.T.¹^ORCID,Krasochko P.A.²^ORCID,Babenka A.S.³^ORCID

Affiliation:

1. Vitebsk State Order of Peoples' Friendship Medical University

2. Vitebsk State Academy of Veterinary Medicine

3. Belarusian State Medical University

Abstract

Usually, the efficacy of antifibrotic drugs is evaluated using laboratory animals. As the modern scientific literature shows, there is still a number of unsolved problems. First, it is necessary to determine the appropriate models that are able to reflect most accurately the development of fibrosis and cirrhosis in humans. Second, to identify diagnostic and prognostic markers to assess the progression / regression of fibrosis in animals. Third, to examine carefully the generally accepted scales for the semi-quantitative assessment of fibrosis in animal models. Based on the findings obtained, we offer an experimental model that has a number of advantages over others. In rats, thioacetamide induces fibrogenesis followed by transformation into cirrhosis. The model allows the study of fibrosis sequentially or at specific stages and is easily reproducible. The developed morphological scale describes fibrogenesis in detail, takes into account intermediate stages, and possesses a diagnostic and prognostic value.

Publisher

Vitebsk State Academy of Veterinary Medicine

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