The immune status of the organism of bulls under cadmium load and the effects of correcting factors
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Published:2022-11-14
Issue:4
Volume:
Page:3-9
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ISSN:2504-5695
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Container-title:EUREKA: Life Sciences
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language:
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Short-container-title:Eureka: LS
Author:
Gutyj BogdanORCID, Martyshuk TetianaORCID, Khariv IvanORCID, Guta ZoryanaORCID
Abstract
Man-made pollution of the environment through food chains has a significant impact on animal productivity and product quality. The studied environmental pollutant, cadmium, is classified as an extremely dangerous heavy metal. That is why the study of the effect of this toxicant on the immune system of the body of young cattle and the development of its correction is relevant. Research in this direction is relevant and has significant prospects. The experiments were carried out on six-month-old bulls, a Ukrainian black-and-white dairy breed. The bulls were subjected to a cadmium load by feeding cadmium chloride with feed at a dose of 0.04 mg/kg of animal body weight. It has been established that the cadmium load in bulls had an immunosuppressive effect on the activity of the immune system, which indicates a decrease in the indicators of humoral and nonspecific parts of the immune defense. To prevent the development of chronic cadmium toxicosis, experimental animals were given the feed additive Metisevit at a dose of 0.36 g/kg of feed and the liposomal preparation Butaintervit at a dose of 5 ml per animal. These preparations contributed to an increase in nonspecific resistance, in particular, an increase in the bactericidal and lysozyme activity of blood serum, phagocytic activity and phagocytic index with a simultaneous decrease in the level of circulating immune complexes in their blood. Under the experimental cadmium load, the best effect on the immune defense of the organism of bulls was exerted by the combined use of the feed additive Metisevit and the liposomal preparation Butaintervit. These changes in the body of young cattle are associated with the complex action of both the components of the feed additive and the liposomal preparation. The liposomal form of Butaintervit has a more pronounced and lasting effect. Metisevit and the liposomal preparation Butaintervit complement the prescribed therapy and, when used together with a cadmium load, show high therapeutic efficacy
Publisher
OU Scientific Route
Subject
General Engineering
Reference24 articles.
1. Slobodian, S. O., Gutyj, B. V., Shalovylo, S. H., Holovach, P. I., Pavliv, O. V., Kalyn, B. M. et. al. (2022). Influence of “Metisevit Plus” feed additive on morphological and biochemical parameters of bull blood under conditions of lead-cadmium loading. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 24 (106), 54–61. doi: https://doi.org/10.32718/nvlvet10609 2. Al-Azemi, M., Omu, F. E., Kehinde, E. O., Anim, J. T., Oriowo, M. A., Omu, A. E. (2010). Lithium protects against toxic effects of cadmium in the rat testes. Journal of Assisted Reproduction and Genetics, 27 (8), 469–476. doi: https://doi.org/10.1007/s10815-010-9426-3 3. Liu, J., Qian, S. Y., Guo, Q., Jiang, J., Waalkes, M. P., Mason, R. P., Kadiiska, M. B. (2008). Cadmium generates reactive oxygen- and carbon-centered radical species in rats: Insights from in vivo spin-trapping studies. Free Radical Biology and Medicine, 45 (4), 475–481. doi: https://doi.org/10.1016/j.freeradbiomed.2008.04.041 4. Peng, L., Wang, X., Huo, X., Xu, X., Lin, K., Zhang, J. et. al. (2015). Blood cadmium burden and the risk of nasopharyngeal carcinoma: a case–control study in Chinese Chaoshan population. Environmental Science and Pollution Research, 22 (16), 12323–12331. doi: https://doi.org/10.1007/s11356-015-4533-4 5. Dieltsova, O. I., Ersteniuk, Kh. M., Khvozdyk, I. M. (2007). Morfo-funktsionalni zminy pechinky i pidshchelepnoi slynnoi zalozy pid vplyvom khlorydu kadmiyu. Morfolohiya, 1 (1), 63–65.
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