The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism-Reference-Cited by-同舟云学术

The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism

Published:2021-03-15 Issue:6 Volume:32 Page:475-491
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Jackson Thomas D.¹,Hock Daniella H.¹,Fujihara Kenji M.²³,Palmer Catherine S.¹,Frazier Ann E.⁴⁵,Low Yau C.⁴⁵,Kang Yilin¹,Ang Ching-Seng⁶,Clemons Nicholas J.²³,Thorburn David R.⁴⁷⁵,Stroud David A.¹,Stojanovski Diana¹

Affiliation:

1. Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute

2. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia

3. Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia

4. Murdoch Children’s Research Institute and

5. Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3052, Australia

6. Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria 3010, Australia

7. Victorian Clinical Genetics Services Royal Children’s Hospital, Melbourne, Victoria 3052, Australia

Abstract

Proteomic profiling of Sengers patient fibroblasts and AGK knockout models identifies remodeling of the mitochondrial proteome, including mitochondrial one-carbon metabolism enzymes, inner membrane serine transporters, sideroflexins, and Complex I subunits and assembly factors.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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5. Adaptive linear step-up procedures that control the false discovery rate

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