Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation-Reference-Cited by-同舟云学术

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

Published:2020-08-01 Issue:17 Volume:31 Page:1879-1891
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Baumhardt Jordan M.¹,Walker Janek S.²,Lee Yoonji³,Shakya Binita¹,Brautigam Chad A.³,Lapalombella Rosa²,Grishin Nick³,Chook Yuh Min¹

Affiliation:

1. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390

2. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210

3. Departments of Biophysics and Microbiology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390

Abstract

Structural and biophysical studies show that CRM1(E571K) binds differently to a small subset of nuclear export signals (NESs). NESs of Mek1, RPS2, and 4E-T bind CRM1(E571K) >10-fold differently, but only 4E-TNES is accessible in the full-length protein. 4E-T is mislocalized to the nucleus in HEK 293 and patient cells carrying CRM1(E571K).

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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